New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective effect on the injury of human umbilical vein endothelial cells

Fitoterapia. 2019 Jan:132:46-52. doi: 10.1016/j.fitote.2018.11.009. Epub 2018 Nov 26.

Abstract

Seven new naphthoquinone derivatives, named eleutherins A-G (1-7), were isolated from the edible bulbs of Eleutherine americana (Hong-Cong), which belongs to the Iridaceae family. Their structures were elucidated on the basis of spectroscopic analysis including high-resolution-electron spray ionization-mass spectrometry (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) techniques. The absolute configurations of compounds 1-4 were determined by experimental and calculated data. Additionally, a hypothetical biosynthetic pathway of 1-7 was postulated. All the isolates were evaluated for their protective effect against the injury of human umbilical vein endothelial cells (HUVECs) in vitro. Eleutherins A and B (1-2) showed a potential protective effect on microvessels.

Keywords: Biosynthetic pathway; Eleutherine americana; HUVECs; Iridaceae family; Naphthoquinone derivatives.

MeSH terms

  • Cells, Cultured
  • China
  • Human Umbilical Vein Endothelial Cells / drug effects*
  • Humans
  • Iridaceae / chemistry*
  • Molecular Structure
  • Naphthoquinones / chemistry*
  • Naphthoquinones / isolation & purification
  • Plant Roots / chemistry
  • Protective Agents / chemistry
  • Protective Agents / isolation & purification

Substances

  • Naphthoquinones
  • Protective Agents