To BBB or Not to BBB?

Jean-Leon Thomas; Anne Eichmann

doi:10.1016/j.devcel.2018.11.039

To BBB or Not to BBB?

Dev Cell. 2018 Dec 17;47(6):689-691. doi: 10.1016/j.devcel.2018.11.039.

Authors

Jean-Leon Thomas¹, Anne Eichmann²

Affiliations

¹ Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France; Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA.
² INSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015 Paris, France; Cardiovascular Research Center and the Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA. Electronic address: anne.eichmann@yale.edu.

PMID: 30562511
DOI: 10.1016/j.devcel.2018.11.039

Abstract

In this issue of Developmental Cell, Anbalagan et al. demonstrate that pituicytes, a subtype of astroglia, drive endothelial cell permeability in the zebrafish embryo neurohypophysis. This occurs via secretion of Vegfa/Tgfβ3 permeability factors that promote formation of fenestrae and the repression of anti-inflammatory retinoic acid signaling that induces tight cell junctions.

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MeSH terms

Animals
Blood-Brain Barrier*
Cues
Permeability
Pituitary Gland, Posterior*
Tight Junctions