A double-hit High-grade B-cell lymphoma with three-way translocation t(3;8;14)(q27;q24;q32) involving BCL6, MYC, and IGH

Elena De Paoli; Laura Bandiera; Emanuele Ravano; Clara Cesana; Giovanni Grillo; Valentina Mancini; Gabriella De Canal; Emanuela Bonoldi; Silvia Soriani

doi:10.1002/ccr3.1871

A double-hit High-grade B-cell lymphoma with three-way translocation t(3;8;14)(q27;q24;q32) involving BCL6, MYC, and IGH

Clin Case Rep. 2018 Oct 26;6(12):2411-2415. doi: 10.1002/ccr3.1871. eCollection 2018 Dec.

Authors

Elena De Paoli¹, Laura Bandiera¹, Emanuele Ravano², Clara Cesana¹, Giovanni Grillo², Valentina Mancini², Gabriella De Canal¹, Emanuela Bonoldi¹, Silvia Soriani¹

Affiliations

¹ Department of Laboratory Medicine ASST Grande Ospedale Metropolitano Niguarda Milan Italy.
² Division of Hematology ASST Grande Ospedale Metropolitano Niguarda Milan Italy.

Abstract

We describe an High-grade B-cell lymphoma case, in which a complex translocation t(3;8;14) with effects on the genes BCL6, MYC, and IGH, was detected. This case could be the first double-hit lymphoma with a single chromosome rearrangement causing the double effect with three genes involved.

Keywords: BCL6; High‐grade B‐cell lymphomas; MYC; double‐hit lymphoma; t(3;8;14); three‐way translocation.

Publication types

Case Reports