New 2-(2-phenylethyl)chromone derivatives from agarwood and their inhibitory effects on tumor cells

Nat Prod Res. 2020 Jun;34(12):1721-1727. doi: 10.1080/14786419.2018.1528591. Epub 2018 Dec 22.

Abstract

Two new chromone derivatives, 7-hydroxy-2-[2-(3'-methoxy-4'-hydroxyphenyl)-ethyl]chromone (1), and 6,7-dimethoxy-2-[2-(3'-hydroxyphenyl)-ethyl]chromone (2) were isolated from the EtOH extract of agarwood of Aquilaria sinensis, together with eleven known analogues. Their structures were established by detailed HR-ESIMS, 1D and 2D NMR spectroscopic analysis, as well as comparison with the literature data. Selected the isolates (1, 2, 4-8, 10, 11) were tested for their antitumor activities against SMMC-7721, MGC-803 and OV-90 cell lines using the MTT method with cisplatin and paclitaxel as the positive control. All the tested compounds showed weak cytotoxic activities with IC50 values ranged from 18.82 to 37.95 µg/ml.

Keywords: 2-(2-phenylethyl)chromone derivatives; Aquilaria sinensis; Whole-tree Agarwood-inducing Technique; agarwood.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Chromones / chemistry
  • Chromones / isolation & purification
  • Chromones / pharmacology
  • Drug Screening Assays, Antitumor
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Thymelaeaceae / chemistry*

Substances

  • Antineoplastic Agents
  • Chromones
  • Flavonoids
  • 2-(2-phenylethyl)chromone