Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development

Naohiro Okada; Shuntaro Ando; Motoyuki Sanada; Sachiko Hirata-Mogi; Yudai Iijima; Hiroshi Sugiyama; Toru Shirakawa; Mika Yamagishi; Akiko Kanehara; Masaya Morita; Tomoko Yagi; Noriyuki Hayashi; Daisuke Koshiyama; Kentaro Morita; Kingo Sawada; Tempei Ikegame; Noriko Sugimoto; Rie Toriyama; Mio Masaoka; Shinya Fujikawa; Sho Kanata; Mariko Tada; Kenji Kirihara; Noriaki Yahata; Tsuyoshi Araki; Seiichiro Jinde; Yukiko Kano; Shinsuke Koike; Kaori Endo; Syudo Yamasaki; Atsushi Nishida; Mariko Hiraiwa-Hasegawa; Miki Bundo; Kazuya Iwamoto; Saori C Tanaka; Kiyoto Kasai

doi:10.1111/pcn.12814

Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development

Psychiatry Clin Neurosci. 2019 May;73(5):231-242. doi: 10.1111/pcn.12814. Epub 2019 Feb 19.

Authors

Naohiro Okada^{1

2}, Shuntaro Ando^{1

3}, Motoyuki Sanada⁴, Sachiko Hirata-Mogi¹, Yudai Iijima^{3

5}, Hiroshi Sugiyama^{1

6}, Toru Shirakawa¹, Mika Yamagishi¹, Akiko Kanehara¹, Masaya Morita¹, Tomoko Yagi⁷, Noriyuki Hayashi¹, Daisuke Koshiyama¹, Kentaro Morita¹, Kingo Sawada¹, Tempei Ikegame^{1

8}, Noriko Sugimoto⁷, Rie Toriyama¹, Mio Masaoka¹, Shinya Fujikawa¹, Sho Kanata^{1

9}, Mariko Tada^{1

2}, Kenji Kirihara¹, Noriaki Yahata^{1

10}, Tsuyoshi Araki¹, Seiichiro Jinde¹, Yukiko Kano⁷, Shinsuke Koike^{1

2

11}, Kaori Endo³, Syudo Yamasaki³, Atsushi Nishida³, Mariko Hiraiwa-Hasegawa¹², Miki Bundo^{8

13}, Kazuya Iwamoto^{8

13}, Saori C Tanaka¹⁴, Kiyoto Kasai^{1

2}

Affiliations

¹ Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan.
³ Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
⁴ Center for Applied Psychological Science, Kwansei Gakuin University, Nishinomiya, Japan.
⁵ Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
⁶ Department of Integrated Educational Sciences, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
⁷ Department of Child Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁸ Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁹ Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
¹⁰ Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
¹¹ UTokyo Institute for Diversity and Adaptation of Human Mind (UTIDAHM), The University of Tokyo, Tokyo, Japan.
¹² Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, Graduate University for Advanced Studies (SOKENDAI), Hayama, Japan.
¹³ Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
¹⁴ Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, Kyoto, Japan.

PMID: 30588712
DOI: 10.1111/pcn.12814

Abstract

Aim: Adolescence is a crucial stage of psychological development and is critically vulnerable to the onset of psychopathology. Our understanding of how the maturation of endocrine, epigenetics, and brain circuit may underlie psychological development in adolescence, however, has not been integrated. Here, we introduce our research project, the population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC), a longitudinal study to explore the neurobiological substrates of development during adolescence.

Methods: Participants in the first wave of the pn-TTC (pn-TTC-1) study were recruited from those of the TTC study, a large-scale epidemiological survey in which 3171 parent-adolescent pairs were recruited from the general population. Participants underwent psychological, cognitive, sociological, and physical assessment. Moreover, adolescents and their parents underwent magnetic resonance imaging (MRI; structural MRI, resting-state functional MRI, and magnetic resonance spectroscopy), and adolescents provided saliva samples for hormone analysis and for DNA analysis including epigenetics. Furthermore, the second wave (pn-TTC-2) followed similar methods as in the first wave.

Results: A total of 301 parent-adolescent pairs participated in the pn-TTC-1 study. Moreover, 281 adolescents participated in the pn-TTC-2 study, 238 of whom were recruited from the pn-TTC-1 sample. The instruction for data request is available at: http://value.umin.jp/data-resource.html.

Conclusion: The pn-TTC project is a large-scale and population-neuroscience-based survey with a plan of longitudinal biennial follow up. Through this approach we seek to elucidate adolescent developmental mechanisms according to biopsychosocial models. This current biomarker research project, using minimally biased samples recruited from the general population, has the potential to expand the new research field of population neuroscience.

Keywords: adolescence; epigenetics; hormone; magnetic resonance imaging; population neuroscience.

MeSH terms

Adolescent
Adolescent Behavior / physiology*
Adolescent Behavior / psychology
Adolescent Development / physiology*
Behavioral Symptoms / epidemiology
Behavioral Symptoms / physiopathology*
Brain / diagnostic imaging*
Electroencephalography*
Epigenesis, Genetic / genetics*
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging*
Male
Neuropsychological Tests*
Parents
Saliva
Tokyo / epidemiology

Abstract

MeSH terms

Grants and funding