A functional genomics approach to identify pathways of drug resistance in medulloblastoma

Kelsey C Bertrand; Claudia C Faria; Patryk Skowron; Amanda Luck; Livia Garzia; Xiaochong Wu; Sameer Agnihotri; Christian A Smith; Michael D Taylor; Stephen C Mack; James T Rutka

doi:10.1186/s40478-018-0652-8

A functional genomics approach to identify pathways of drug resistance in medulloblastoma

Acta Neuropathol Commun. 2018 Dec 27;6(1):146. doi: 10.1186/s40478-018-0652-8.

Authors

Kelsey C Bertrand^{1

2}, Claudia C Faria³, Patryk Skowron^{4

5

6

7}, Amanda Luck^{4

5

6

7}, Livia Garzia^{4

5

6

7}, Xiaochong Wu^{4

5

6

7}, Sameer Agnihotri⁸, Christian A Smith^{4

5

6

7}, Michael D Taylor^{4

5

6

7}, Stephen C Mack^{9

10}, James T Rutka^{11

12

13

14}

Affiliations

¹ Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, USA.
² Brain Tumor Program, Cancer and Hematology Centers, Texas Children's Hospital, Houston, USA.
³ Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal.
⁴ Department of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.
⁵ Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Canada.
⁶ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
⁷ Department of Neurosurgery, The Hospital for Sick Children, Toronto, Canada.
⁸ Department of Neurological Surgery, Children's Hospital, University of Pittsburgh School of Medicine, Pittsburgh, USA.
⁹ Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, USA. stephen.mack@bcm.edu.
¹⁰ Brain Tumor Program, Cancer and Hematology Centers, Texas Children's Hospital, Houston, USA. stephen.mack@bcm.edu.
¹¹ Department of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada. james.rutka@sickkids.ca.
¹² Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Canada. james.rutka@sickkids.ca.
¹³ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. james.rutka@sickkids.ca.
¹⁴ Department of Neurosurgery, The Hospital for Sick Children, Toronto, Canada. james.rutka@sickkids.ca.

No abstract available

Keywords: Brain tumor; Cancer; Drug resistance; Functional genomics; Medulloblastoma; Sleeping beauty; Transposon mutagenesis.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Anilides / adverse effects
Animals
Cerebellar Neoplasms / drug therapy
Cerebellar Neoplasms / genetics*
Cerebellar Neoplasms / mortality
Disease Models, Animal
Drug Delivery Systems
Drug Resistance, Neoplasm / genetics*
Gene Regulatory Networks
Genomics / methods*
Humans
Medulloblastoma / drug therapy
Medulloblastoma / genetics*
Medulloblastoma / mortality
Mice
Mice, Transgenic
Mutation / genetics
Patched-1 Receptor / genetics
Patched-1 Receptor / metabolism
Quinolines / adverse effects
Signal Transduction / genetics*
Transposases / genetics*

Substances

Anilides
GSK 1363089
PTCH1 protein, human
Patched-1 Receptor
Quinolines
Transposases
sleeping beauty transposase, human

Publication types

MeSH terms

Substances

Grants and funding