Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies

Neşe Çakmak-Görür; Josefine Radke; Simone Rhein; Elisa Schumann; Gerald Willimsky; Frank L Heppner; Thomas Blankenstein; Antonio Pezzutto

doi:10.1038/s41375-018-0330-7

Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies

Leukemia. 2019 Apr;33(4):1039-1043. doi: 10.1038/s41375-018-0330-7. Epub 2019 Jan 3.

Authors

Neşe Çakmak-Görür^#^{1

2

3}, Josefine Radke^#^{4

5

6}, Simone Rhein^{7

4}, Elisa Schumann^{5

6}, Gerald Willimsky^{6

8

9}, Frank L Heppner^{4

5

6

10}, Thomas Blankenstein^{11

4

8}, Antonio Pezzutto^{11

7

4}

Affiliations

¹ Max Delbrück Center for Molecular Medicine in Helmholtz Association, Berlin, Germany. nese.cakmak@mdc-berlin.de.
² Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. nese.cakmak@mdc-berlin.de.
³ Berlin Institute of Health (BIH), Berlin, Germany. nese.cakmak@mdc-berlin.de.
⁴ Berlin Institute of Health (BIH), Berlin, Germany.
⁵ Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁶ German Cancer Consortium (DKTK), Heidelberg, Germany, Partner Site Berlin, Berlin, Germany.
⁷ Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁸ Institute of Immunology, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
⁹ German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁰ German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
¹¹ Max Delbrück Center for Molecular Medicine in Helmholtz Association, Berlin, Germany.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / metabolism
Cells, Cultured
HLA-A2 Antigen / immunology*
HLA-A2 Antigen / metabolism
Humans
Immunotherapy, Adoptive*
K562 Cells
Mice
Purkinje Cells / immunology*
Purkinje Cells / metabolism
Receptors, Antigen, T-Cell / metabolism
fms-Like Tyrosine Kinase 3 / metabolism*

Substances

HLA-A2 Antigen
Receptors, Antigen, T-Cell
Flt3 protein, mouse
fms-Like Tyrosine Kinase 3