Huntington Disease's Glial Progenitor Cells Hit the Pause Button in the Mouse Brain

Nan Wang; X William Yang

doi:10.1016/j.stem.2018.12.004

Huntington Disease's Glial Progenitor Cells Hit the Pause Button in the Mouse Brain

Cell Stem Cell. 2019 Jan 3;24(1):3-4. doi: 10.1016/j.stem.2018.12.004.

Authors

Nan Wang¹, X William Yang²

Affiliations

¹ Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
² Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: xwyang@mednet.ucla.edu.

PMID: 30609397
DOI: 10.1016/j.stem.2018.12.004

Abstract

White matter abnormalities are prominent neuropathological features in Huntington's disease (HD); however, the cellular culprits are unclear. In this issue of Cell Stem Cell, Osipovitch et al. (2019) show that patient-derived glial progenitor cells fail to properly differentiate and myelinate in the mouse brain due to cell-intrinsic transcriptional defects.

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MeSH terms

Animals
Brain
Cell Differentiation
Humans
Huntington Disease*
Mice
Neuroglia
Stem Cells