Chromosomes: Keeping Centromeric Chromatin Tidy through S Phase

Jennine M Dawicki-McKenna; Ben E Black

doi:10.1016/j.cub.2018.11.044

Chromosomes: Keeping Centromeric Chromatin Tidy through S Phase

Curr Biol. 2019 Jan 7;29(1):R35-R37. doi: 10.1016/j.cub.2018.11.044.

Authors

Jennine M Dawicki-McKenna¹, Ben E Black²

Affiliations

¹ Department of Biochemistry and Biophysics and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Biochemistry and Biophysics and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: blackbe@pennmedicine.upenn.edu.

PMID: 30620916
DOI: 10.1016/j.cub.2018.11.044

Abstract

The centromere, the chromosomal locus where the kinetochore is assembled in mitosis, is defined epigenetically, and its location must be remembered with each cell cycle. Recent studies elucidate how centromere identity is faithfully maintained despite challenges imposed by DNA replication.

Publication types

Comment

MeSH terms

Centromere
Centromere Protein A
Chromatin*
Chromosomal Proteins, Non-Histone
DNA Replication
Nucleosomes*
S Phase

Substances

Centromere Protein A
Chromatin
Chromosomal Proteins, Non-Histone
Nucleosomes