Podosomes are actin-based microdomains connecting the cell with its extracellular matrix. Contractile actin-myosin cables assemble them into a network that constitutes a versatile cellular superstructure. Discovered and extensively described in in vitro conditions, podosomes now appear as major actors of specific physiological processes. They share common characteristics but their morphology and their effect on cell functioning can only be apprehended in specific cellular contexts. We focus here on three cellular processes involving podosomes and discuss their properties in context.
© 2018 médecine/sciences – Inserm.