Rh (D) alloimmunization treated by double filtration plasmapheresis

Sibel Gokcay Bek; Necmi Eren; Ant Uzay; Serkan Bakirdogen

doi:10.1016/j.transci.2018.12.002

Rh (D) alloimmunization treated by double filtration plasmapheresis

Transfus Apher Sci. 2019 Feb;58(1):83-86. doi: 10.1016/j.transci.2018.12.002. Epub 2018 Dec 8.

Authors

Sibel Gokcay Bek¹, Necmi Eren², Ant Uzay³, Serkan Bakirdogen⁴

Affiliations

¹ Kocaeli University Hospital, Nephrology Department, Kocaeli, Turkey. Electronic address: sibel.bek@kou.edu.tr.
² Kocaeli University Hospital, Nephrology Department, Kocaeli, Turkey.
³ Acibadem University Hospital, Hematology Department, Istanbul, Turkey.
⁴ Canakkale 18 Mart University Hospital, Nephrology Department, Canakkale, Turkey. Electronic address: serkanbakirdogen@hotmail.com.

PMID: 30639085
DOI: 10.1016/j.transci.2018.12.002

Abstract

Here in this report a 31 year old pregnant woman with positive serum antiglobulin test against anti-D antierythrocyte antibodies who was treated succesfully with double filtration plasmapheresis (DFPP) is presented. The DFPP was started in the early stage of pregnancy together with intravenous immunoglobulin therapy and the antierythrocyte antibody titer of the patient was successfully maintained in a stable level below 1:64 dilution. She delivered successfully on the 30th week of gestation. The favorable outcome of this patient implies that DFPP is an effective and safe treatment modality in pregnant women with red cell alloimmunization.

Keywords: Double plasmapheresis; Pregnancy; Rh alloimmunization.

Publication types

Case Reports

MeSH terms

Adult
Female
Humans
Plasmapheresis / methods*
Pregnancy
Rh Isoimmunization / blood*
Rho(D) Immune Globulin / blood*

Substances

RHO(D) antibody
Rho(D) Immune Globulin