Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition

Affiliations

• ¹ Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology (B.M.B., L.G.F., H.R., G.Å.V., M.E.G., K.H., B.O.Å.), NTNU, Norwegian University of Science and Technology, Trondheim.
• ² MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom (B.M.B., J.Z., H.R., G.D.S.).
• ³ Clinic of Thoracic and Occupational Medicine (B.M.B.), St. Olavs Hospital, Trondheim University Hospital, Norway.
• ⁴ Department of Biostatistics and Center for Statistical Genetics (L.G.F., C.W.), University of Michigan, Ann Arbor, MI.
• ⁵ Department of Internal Medicine (J.B.N., I.S., S.E.G., C.W.), University of Michigan, Ann Arbor, MI.
• ⁶ Cardiology Unit (M.M.), Karolinska Institutet, Stockholm, Sweden.
• ⁷ Cardiovascular Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine (M.M., F.M.v.H.), Karolinska Institutet, Stockholm, Sweden.
• ⁸ Department of Public Health and Nursing (G.Å.V., L.E.L., L.J.V., I.J.), NTNU, Norwegian University of Science and Technology, Trondheim.
• ⁹ Department of Circulation and Medical Imaging (L.E.L.), NTNU, Norwegian University of Science and Technology, Trondheim.
• ¹⁰ Department of Cardiology (L.E.L.), St. Olavs Hospital, Trondheim University Hospital, Norway.
• ¹¹ Research Institute of Internal Medicine (P.A., T.U.), Oslo University Hospital, Rikshospitalet.
• ¹² Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital, Rikshospitalet.
• ¹³ Institute of Clinical Medicine (P.A.), University of Oslo, Norway.
• ¹⁴ Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research (J.K.D.), NTNU, Norwegian University of Science and Technology, Trondheim.
• ¹⁵ Department of Infectious Diseases (J.K.D.), St. Olavs Hospital, Trondheim University Hospital, Norway.
• ¹⁶ University of Oslo, Norway (T.U.).
• ¹⁷ K.G. Jebsen TREC, University of Tromsø, Norway (T.U.).
• ¹⁸ Division of Clinical Neuroscience, Oslo University Hospital (J.-A.Z.), University of Oslo, Norway.
• ¹⁹ Laboratory of Biochemical Neuroendocrinology, IRCM, Montreal, Quebec, Canada (N.G.S.).
• ²⁰ Department of Human Genetics (C.W.), University of Michigan, Ann Arbor, MI.
• ²¹ Department of Endocrinology (B.O.Å.), St. Olavs Hospital, Trondheim University Hospital, Norway.