Coronin-1, King of Alloimmunity

Immunity. 2019 Jan 15;50(1):3-5. doi: 10.1016/j.immuni.2018.12.030.

Abstract

Defining pathways that differentially regulate graft-reactive versus anti-microbial T cell responses could facilitate more precise manipulation of immune responses in the context of organ and tissue transplantation. Here, Jayachandran et al. (2019) identify a coronin-1-PDE4-cAMP axis that, when perturbed, results in the induction of transplantation tolerance while maintaining anti-microbial immunity.

Publication types

  • Comment

MeSH terms

  • Immunity
  • Microfilament Proteins / immunology*
  • Signal Transduction
  • T-Lymphocytes*
  • Transplantation Tolerance*

Substances

  • Microfilament Proteins
  • coronin proteins