Abdominal pain in combination with an unexplained hemolytic anemia are crucial signs to test for paroxysmal nocturnal hemoglobinuria: A case report

N S Elias; Jürgen Riedl; Karlijn Stouten; Mark-David Levin; Frank Wolfhagen; Mathijs Eefting; Henricus Jan Vermeer

doi:10.1002/ccr3.1771

Abdominal pain in combination with an unexplained hemolytic anemia are crucial signs to test for paroxysmal nocturnal hemoglobinuria: A case report

Clin Case Rep. 2018 Dec 4;7(1):175-179. doi: 10.1002/ccr3.1771. eCollection 2019 Jan.

Authors

N S Elias^{1

2}, Jürgen Riedl^{1

2}, Karlijn Stouten^{1

2}, Mark-David Levin³, Frank Wolfhagen³, Mathijs Eefting⁴, Henricus Jan Vermeer^{1

2}

Affiliations

¹ Department of Clinical Chemistry Albert Schweitzer Hospital Dordrecht The Netherlands.
² Result Laboratory Dordrecht The Netherlands.
³ Department of Internal Medicine Albert Schweitzer Hospital Dordrecht The Netherlands.
⁴ Department of Hematology Beatrix Hospital Gorinchem The Netherlands.

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH), a rare benign hematological disorder, presents with a wide variety of clinical symptoms. A direct Coombs-negative hemolytic anemia combined with an increased LDH = Lactate dehydrogenase level are signs to test for PNH. Follow-up does not need any microscopic review's only flow cytometric PNH clone size.

Keywords: Coombs‐negative hemolysis; Paroxysmal nocturnal hemoglobinuria; abdominal pain; flow cytometry; hemolytic anemia.

Publication types

Case Reports