Gamma tocopherol effect on LPS-induced sputum neutrophilia is not modified by BMI or GSTM1 genotype

J Allergy Clin Immunol. 2019 May;143(5):1937-1939. doi: 10.1016/j.jaci.2018.12.1009. Epub 2019 Jan 17.

Abstract

Gamma tocopherol may be beneficial as a primary or complementary therapeutic agent in conditions with neutrophilic airway inflammation. Its effects are not modified by BMI or GSTM1 genotype, allowing for its use in a broader population.

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Body Mass Index*
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Lipopolysaccharides / pharmacology*
  • Male
  • Middle Aged
  • Neutrophils / drug effects*
  • Sputum / cytology
  • Sputum / drug effects*
  • Young Adult
  • gamma-Tocopherol / pharmacology*

Substances

  • Lipopolysaccharides
  • gamma-Tocopherol
  • Glutathione Transferase
  • glutathione S-transferase M1