Risk of Latent Tuberculosis Reactivation After Hematopoietic cell Transplantation

Clin Infect Dis. 2019 Aug 16;69(5):869-872. doi: 10.1093/cid/ciz048.

Abstract

There were no cases of tuberculosis in a cohort of 2531 patients who underwent hematopoietic cell transplantation from 2010 to 2015 after 7323 person-years of follow up (95% confidence interval [CI], 0.0-0.05 cases/100 person-years), including 29 (1.15%) patients with untreated latent tuberculosis after 89 person-years of follow-up (95% CI, 0.0-4.06 cases/100 person-years).

Keywords: Mycobacterium tuberculosis; LTBI; TB; allogeneic; hematopoietic cell transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antitubercular Agents / therapeutic use
  • Female
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Latent Tuberculosis / epidemiology
  • Latent Tuberculosis / microbiology*
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis / growth & development*
  • Retrospective Studies
  • Risk Factors
  • Tuberculin Test
  • Young Adult

Substances

  • Antitubercular Agents