The Brazilian Reproducibility Initiative

Olavo B Amaral; Kleber Neves; Ana P Wasilewska-Sampaio; Clarissa Fd Carneiro

doi:10.7554/eLife.41602

The Brazilian Reproducibility Initiative

Elife. 2019 Feb 5:8:e41602. doi: 10.7554/eLife.41602.

Authors

Olavo B Amaral¹, Kleber Neves¹, Ana P Wasilewska-Sampaio¹, Clarissa Fd Carneiro¹

Affiliation

¹ Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

Most efforts to estimate the reproducibility of published findings have focused on specific areas of research, even though science is usually assessed and funded on a regional or national basis. Here we describe a project to assess the reproducibility of findings in biomedical science published by researchers based in Brazil. The Brazilian Reproducibility Initiative is a systematic, multicenter effort to repeat between 60 and 100 experiments: the project will focus on a set of common methods, repeating each experiment in three different laboratories from a countrywide network. The results, due in 2021, will allow us to estimate the level of reproducibility of biomedical science in Brazil, and to investigate what aspects of the published literature might help to predict whether a finding is reproducible.

Keywords: Brazil; biochemistry; biomedical research; cell biology; chemical biology; metascience; mouse; open science; rat; replication; reproducibility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biochemistry / methods*
Biomedical Research / methods*
Brazil
Reproducibility of Results*

Grants and funding

The project's funder (Instituto Serrapilheira) made suggestions on the study design, but had no role in data collection and interpretation, or in the decision to submit the work for publication. KN and APWS are supported by post-doctoral scholarships within this project. CFDC is supported by a PhD scholarship from CNPq.