Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation

M Rondanelli; A M Castellazzi; A Riva; P Allegrini; M A Faliva; G Peroni; M Naso; M Nichetti; C Tagliacarne; C Valsecchi; T Fazia; S Perna; F Graziano; M Grassi; L Bernardinelli

doi:10.1155/2019/2069701

Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation

Evid Based Complement Alternat Med. 2019 Jan 6:2019:2069701. doi: 10.1155/2019/2069701. eCollection 2019.

Authors

M Rondanelli^{1

2}, A M Castellazzi³, A Riva⁴, P Allegrini⁴, M A Faliva⁵, G Peroni⁵, M Naso⁵, M Nichetti⁵, C Tagliacarne³, C Valsecchi³, T Fazia⁶, S Perna⁷, F Graziano⁶, M Grassi⁶, L Bernardinelli⁶

Affiliations

¹ IRCCS Mondino Foundation, Italy.
² Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Italy.
³ Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
⁴ Research and Development Unit, Indena, Milan, Italy.
⁵ Endocrinology and Nutrition Unit, Section of Human Nutrition, ASP Pavia, University of Pavia, 27100, Pavia, Italy.
⁶ Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy.
⁷ Department of Biology, College of Science, University of Bahrain, Sakhir Campus, P.O. Box 32038, Bahrain.

Abstract

The aim of the present study is to evaluate the effects of 60-day artichoke leaf extract (ALE) supplementation (250mg, twice daily) on cytokines levels, natural killer cell (NK) response, and lipo-metabolic profile (HDL, LDL, and total-cholesterol, triglycerides (TG), ApoB, ApoA, lipid accumulation product (LAP), glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR)) in twenty adults (9/11 males/females, age=49.10 ± 13.74 years, and BMI=33.12 ± 5.14 kg/m²) with low HDL-C and mild hypercholesterolemia. Hierarchical generalized linear model, adjusted for sex, BMI, and age, has been used to evaluate pre-post treatment changes. A significant increase for HDL-C (β=0.14, p=0.0008) and MCP-1 (β=144.77, p=0.004) and a significant decrease for ApoB/ApoA (β=-0.07, p=0.03), total-C/HDL-C ratio (β=-0.58, p<0.001), and NK response at stimulus low (β=0.43, p=0.04), medium (β=0.40, p<0.001), and high (β=0.42, p=0.001) have been found. These results support the benefits of ALE supplementation on metabolic profile.