Interplay between epigenetic abnormalities and deregulated expression of microRNAs in cancer

Semin Cancer Biol. 2019 Oct:58:47-55. doi: 10.1016/j.semcancer.2019.02.003. Epub 2019 Feb 8.

Abstract

Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.

Keywords: Epigenetic regulation; Non-coding RNAs; miRNAs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Carcinogenesis / genetics
  • Epigenesis, Genetic / genetics*
  • Epigenomics / methods
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • MicroRNAs / genetics*
  • Neoplasms / genetics*
  • Oncogenes / genetics
  • RNA, Untranslated / genetics

Substances

  • MicroRNAs
  • RNA, Untranslated