Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Meng-Meng Zhang; Na Liu; Yuan-Liang Zhang; Bowen Rong; Xiao-Lin Wang; Chun-Hui Xu; Yin-Yin Xie; Shuhong Shen; Jiang Zhu; Stephen D Nimer; Zhu Chen; Sai-Juan Chen; Robert G Roeder; Fei Lan; Lan Wang; Qiu-Hua Huang; Xiao-Jian Sun

doi:10.1038/s41375-019-0398-8

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Leukemia. 2019 Jul;33(7):1822-1827. doi: 10.1038/s41375-019-0398-8. Epub 2019 Feb 12.

Authors

Meng-Meng Zhang¹, Na Liu², Yuan-Liang Zhang¹, Bowen Rong³, Xiao-Lin Wang¹, Chun-Hui Xu², Yin-Yin Xie¹, Shuhong Shen⁴, Jiang Zhu¹, Stephen D Nimer⁵, Zhu Chen¹, Sai-Juan Chen¹, Robert G Roeder⁶, Fei Lan³, Lan Wang⁷, Qiu-Hua Huang⁸, Xiao-Jian Sun⁹

Affiliations

¹ State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
³ Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
⁴ Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁵ Department of Biochemistry and Molecular Biology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
⁶ Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, USA.
⁷ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. lwang@sibs.ac.cn.
⁸ State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hqh10632@rjh.com.cn.
⁹ State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xjsun@sibs.ac.cn.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / antagonists & inhibitors*
Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
CCAAT-Enhancer-Binding Protein-alpha / genetics
CCAAT-Enhancer-Binding Protein-alpha / metabolism*
Cell Differentiation*
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Core Binding Factor Alpha 2 Subunit / chemistry*
Core Binding Factor Alpha 2 Subunit / genetics
Core Binding Factor Alpha 2 Subunit / metabolism
Gene Expression Regulation, Neoplastic*
Humans
Inhibitor of Differentiation Protein 1 / genetics
Inhibitor of Differentiation Protein 1 / metabolism
Leukemia / genetics
Leukemia / metabolism
Leukemia / pathology*
Mice
Neoplasm Proteins / antagonists & inhibitors*
Neoplasm Proteins / genetics
Neoplasm Proteins / metabolism
Oncogene Proteins, Fusion / chemistry*
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Fusion / metabolism
RUNX1 Translocation Partner 1 Protein / chemistry*
RUNX1 Translocation Partner 1 Protein / genetics
RUNX1 Translocation Partner 1 Protein / metabolism
T-Cell Acute Lymphocytic Leukemia Protein 1 / genetics
T-Cell Acute Lymphocytic Leukemia Protein 1 / metabolism
Translocation, Genetic*
Tumor Cells, Cultured
Xenograft Model Antitumor Assays

Substances

AML1-ETO fusion protein, human
Basic Helix-Loop-Helix Transcription Factors
Biomarkers, Tumor
CCAAT-Enhancer-Binding Protein-alpha
Core Binding Factor Alpha 2 Subunit
ID1 protein, human
Inhibitor of Differentiation Protein 1
LYL1 protein, human
Neoplasm Proteins
Oncogene Proteins, Fusion
RUNX1 Translocation Partner 1 Protein
T-Cell Acute Lymphocytic Leukemia Protein 1
TAL1 protein, human

Publication types

MeSH terms

Substances

Grants and funding