Neuroendocrine prostate carcinoma cells originate from the p63-expressing basal cells but not the pre-existing adenocarcinoma cells in mice

Cell Res. 2019 May;29(5):420-422. doi: 10.1038/s41422-019-0149-4. Epub 2019 Feb 18.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology*
  • Animals
  • Cell Differentiation
  • Cell Line, Tumor
  • Keratin-14 / metabolism
  • Male
  • Mice
  • Mice, SCID
  • Mice, Transgenic
  • Neoplasms, Basal Cell / metabolism
  • Neoplasms, Basal Cell / pathology*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology*
  • Rats
  • Receptors, Androgen / genetics
  • Receptors, Androgen / metabolism
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Transplantation, Heterologous

Substances

  • Keratin-14
  • Receptors, Androgen
  • Trans-Activators
  • Trp63 protein, mouse