Abstract
Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipates / chemistry
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Amino Acid Sequence
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Chemistry Techniques, Synthetic
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Glycoconjugates / chemical synthesis*
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Glycoconjugates / chemistry*
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Glycopeptides / chemical synthesis
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Glycopeptides / chemistry
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Models, Molecular
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Molecular Conformation
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Substrate Specificity
Substances
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Adipates
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Glycoconjugates
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Glycopeptides
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adipic acid