Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association

Pathol Res Pract. 2019 May;215(5):1089-1092. doi: 10.1016/j.prp.2019.01.039. Epub 2019 Jan 28.

Abstract

It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.

Keywords: Breast cancer; Imunohistochemistry; Tamoxifen; UTROSCT; Uterine tumor resembling ovarian sex cord tumor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Breast Neoplasms / drug therapy
  • Carcinoma, Ductal, Breast / drug therapy
  • Comorbidity
  • Female
  • Humans
  • Leiomyoma / epidemiology
  • Leiomyoma / surgery
  • Middle Aged
  • Selective Estrogen Receptor Modulators / adverse effects*
  • Sex Cord-Gonadal Stromal Tumors / chemically induced*
  • Tamoxifen / adverse effects*
  • Uterine Neoplasms / chemically induced*

Substances

  • Selective Estrogen Receptor Modulators
  • Tamoxifen