Galectin-3 is essential for IgE-dependent activation of human basophils by A549 lung epithelial cells

John T Schroeder; Abiodun A Adeosun; Danh Do; Anja P Bieneman

doi:10.1016/j.jaci.2019.03.001

Galectin-3 is essential for IgE-dependent activation of human basophils by A549 lung epithelial cells

J Allergy Clin Immunol. 2019 Jul;144(1):312-315.e1. doi: 10.1016/j.jaci.2019.03.001. Epub 2019 Mar 9.

Authors

John T Schroeder¹, Abiodun A Adeosun², Danh Do², Anja P Bieneman²

Affiliations

¹ Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Md. Electronic address: schray@jhmi.edu.
² Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Md.

Abstract

Using novel co-culture model systems, galectin-3 is shown to facilitate basophil secretion of IL-4/IL-13, with implications that this unique mode of activation may be linked to a variety of diseases ranging from asthma to cancer.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

A549 Cells
Basophils / metabolism*
Blood Proteins
Coculture Techniques
Galectin 3 / genetics
Galectin 3 / metabolism*
Galectins
Humans
Immunoglobulin E / metabolism*
Interleukin-13 / metabolism
RNA, Small Interfering / genetics
Recombinant Proteins / metabolism

Substances

Blood Proteins
Galectin 3
Galectins
Interleukin-13
LGALS3 protein, human
RNA, Small Interfering
Recombinant Proteins
Immunoglobulin E

Abstract

Publication types

MeSH terms

Substances

Grants and funding