Unexpected systemic phenotypes result from focal combined deficiencies of forebrain insulin receptor/IGF-1 receptor signaling

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):5852-5854. doi: 10.1073/pnas.1901970116. Epub 2019 Mar 11.

Authors

Sam Gandy^{1

2

3}, Derek M Huffman^{4

5}

Affiliations

¹ The NFL Neurological Program, Center for Cognitive Health, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; samuel.gandy@mssm.edu.
² Alzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
³ Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
⁴ Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461.
⁵ Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Amygdala
Hippocampus
Insulins*
Phenotype
Prosencephalon
Receptor, IGF Type 1 / genetics*
Receptor, Insulin / genetics

Substances

Insulins
Receptor, IGF Type 1
Receptor, Insulin

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