Repeatability and reproducibility of 3D MR fingerprinting relaxometry measurements in normal breast tissue

Abstract

Background: The 3D breast magnetic resonance fingerprinting (MRF) technique enables T₁ and T₂ mapping in breast tissues. Combined repeatability and reproducibility studies on breast T₁ and T₂ relaxometry are lacking.

Purpose: To assess test-retest and two-visit repeatability and interscanner reproducibility of the 3D breast MRF technique in a single-institution setting.

Study type: Prospective.

Subjects: Eighteen women (median age 29 years, range, 22-33 years) underwent Visit 1 scans on scanner 1. Ten of these women underwent test-retest scan repositioning after a 10-minute interval. Thirteen women had Visit 2 scans within 7-15 days in same menstrual cycle. The remaining five women had Visit 2 scans in the same menstrual phase in next menstrual cycle. Five women were also scanned on scanner 2 at both visits for interscanner reproducibility.

Field strength/sequence: Two 3T MR scanners with the 3D breast MRF technique.

Assessment: T₁ and T₂ MRF maps of both breasts.

Statistical tests: Mean T₁ and T₂ values for normal fibroglandular tissues were quantified at all scans. For variability, between and within-subjects coefficients of variation (bCV and wCV, respectively) were assessed. Repeatability was assessed with Bland-Altman analysis and coefficient of repeatability (CR). Reproducibility was assessed with interscanner coefficient of variation (CoV) and Wilcoxon signed-rank test.

Results: The bCV at test-retest scans was 9-12% for T₁ , 7-17% for T₂ , wCV was <4% for T₁ , and <7% for T₂ . For two visits in same menstrual cycle, bCV was 10-15% for T₁ , 13-17% for T₂ , wCV was <7% for T₁ and <5% for T₂ . For two visits in the same menstrual phase, bCV was 6-14% for T₁ , 15-18% for T₂ , wCV was <7% for T₁ , and <9% for T₂ . For test-retest scans, CR for T₁ and T₂ were 130 msec and 11 msec. For two visit scans, CR was <290 msec for T₁ and 10-14 msec for T₂ . Interscanner CoV was 3.3-3.6% for T₁ and 5.1-6.6% for T₂ , with no differences between interscanner measurements (P = 1.00 for T₁ , P = 0.344 for T₂ ).

Data conclusion: 3D breast MRF measurements are repeatable across scan timings and scanners and may be useful in clinical applications in breast imaging.

Level of evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1133-1143.

Keywords: breast; magnetic resonance fingerprinting; quantitative imaging; relaxometry; repeatability.