The role of vitamin D and P2X7R in multiple sclerosis

Veronica Tsin Fong Voo; Terence O'Brien; Helmut Butzkueven; Mastura Monif

doi:10.1016/j.jneuroim.2019.03.004

The role of vitamin D and P2X7R in multiple sclerosis

J Neuroimmunol. 2019 May 15:330:159-169. doi: 10.1016/j.jneuroim.2019.03.004. Epub 2019 Mar 14.

Authors

Veronica Tsin Fong Voo¹, Terence O'Brien², Helmut Butzkueven³, Mastura Monif⁴

Affiliations

¹ Department of Physiology, The University of Melbourne, Melbourne, Australia; Department of Neuroscience, Monash University, Melbourne, Australia.
² Department of Neuroscience, Monash University, Melbourne, Australia; Department of Neurology, Melbourne Health, Melbourne, Australia.
³ Department of Neuroscience, Monash University, Melbourne, Australia.
⁴ Department of Physiology, The University of Melbourne, Melbourne, Australia; Department of Neuroscience, Monash University, Melbourne, Australia; Department of Neurology, Melbourne Health, Melbourne, Australia. Electronic address: mastura.monif@monash.edu.

PMID: 30908981
DOI: 10.1016/j.jneuroim.2019.03.004

Abstract

Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

Keywords: Innate immunity; Monocytes; Multiple sclerosis; Neuroinflammation; P2X7R; Vitamin D.

Publication types

Review

MeSH terms

Humans
Multiple Sclerosis / blood*
Multiple Sclerosis / drug therapy
Multiple Sclerosis / epidemiology
Receptors, Purinergic P2X7 / blood*
Vitamin D / physiology*
Vitamin D / therapeutic use
Vitamin D Deficiency / blood*
Vitamin D Deficiency / drug therapy
Vitamin D Deficiency / epidemiology

Substances

Receptors, Purinergic P2X7
Vitamin D