Anti-NMDAR encephalitis preceded by non-herpetic central nervous system infection: Systematic literature review and first case of tick-borne encephalitis triggering anti-NMDAR encephalitis

Elena Cavaliere; Margherita Nosadini; Maria Federica Pelizza; Giulia Ventura; Irene Toldo; Stefano Sartori

doi:10.1016/j.jneuroim.2019.03.011

Anti-NMDAR encephalitis preceded by non-herpetic central nervous system infection: Systematic literature review and first case of tick-borne encephalitis triggering anti-NMDAR encephalitis

J Neuroimmunol. 2019 Jul 15:332:1-7. doi: 10.1016/j.jneuroim.2019.03.011. Epub 2019 Mar 19.

Authors

Elena Cavaliere¹, Margherita Nosadini², Maria Federica Pelizza¹, Giulia Ventura³, Irene Toldo¹, Stefano Sartori⁴

Affiliations

¹ Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Italy.
² Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Italy; Neuroimmunology group, Pediatric Research Institute "Città della Speranza", Padova, Italy. Electronic address: margherita.nosadini@gmail.com.
³ Paediatric Unit, Santa Maria degli Angeli Hospital, Pordenone, Italy.
⁴ Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Italy; Neuroimmunology group, Pediatric Research Institute "Città della Speranza", Padova, Italy.

PMID: 30913507
DOI: 10.1016/j.jneuroim.2019.03.011

Abstract

After the recent description of biphasic disease with herpes simplex virus (HSV) encephalitis followed by anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE), anti-NMDARE preceded by non-HSV central nervous system (CNS) infection has been more rarely reported. We report the first case of TBE followed by anti-NMDARE and carry out a systematic literature review on anti-NMDARE preceded by non-HSV CNS infection.

Keywords: Anti-N-methyl-d-aspartate receptor encephalitis; Anti-NMDAR encephalitis; Children; Tick-borne encephalitis.

Publication types

Case Reports
Systematic Review

MeSH terms

Anti-N-Methyl-D-Aspartate Receptor Encephalitis / etiology*
Anti-N-Methyl-D-Aspartate Receptor Encephalitis / immunology
Anti-N-Methyl-D-Aspartate Receptor Encephalitis / therapy
Antibodies, Viral / blood
Antibodies, Viral / cerebrospinal fluid
Autoantibodies / blood
Autoantibodies / cerebrospinal fluid
Child
Combined Modality Therapy
Encephalitis Viruses, Tick-Borne / immunology
Encephalitis, Japanese / complications
Encephalitis, Tick-Borne / complications*
Encephalitis, Tick-Borne / immunology
Female
HIV Infections / complications
Herpesviridae Infections / complications
Humans
Immunoglobulins, Intravenous / therapeutic use
Immunosuppressive Agents / therapeutic use
Oligoclonal Bands / cerebrospinal fluid
Plasma Exchange
Shock, Septic / etiology
Strongylida Infections / complications
Tuberculosis, Meningeal / complications

Substances

Antibodies, Viral
Autoantibodies
Immunoglobulins, Intravenous
Immunosuppressive Agents
Oligoclonal Bands

Supplementary concepts

Angiostrongyliasis