Knee pain is common among children and adolescents, and the most usual knee conditions are patellofemoral pain and Osgood-Schlatter disease. Long-standing knee pain often leads to reduced physical activity levels, and one in two continue to experience knee pain for years. Education of the patients and strategies to improve the ability of them to manage knee pain should be the mainstay of treatment for these types of knee pain. This review outlines current evidence on the managing of knee pain in children and adolescents and sets it into the context of a clinical care pathway from primary to secondary care.