Pain Measurement in Rheumatic and Musculoskeletal Diseases: Where To Go from Here? Report from a Special Interest Group at OMERACT 2018

Alessandro Chiarotto; Ulrike Kaiser; Ernest Choy; Robin Christensen; Philip G Conaghan; Mary Cowern; Michael Gill; Maarten de Wit; Elizabeth Gargon; Ben Horgan; Jamie J Kirkham; Lee S Simon; Jasvinder A Singh; Peter Tugwell; Dennis C Turk; Philip J Mease

doi:10.3899/jrheum.181099

Pain Measurement in Rheumatic and Musculoskeletal Diseases: Where To Go from Here? Report from a Special Interest Group at OMERACT 2018

J Rheumatol. 2019 Oct;46(10):1355-1359. doi: 10.3899/jrheum.181099. Epub 2019 Apr 1.

Authors

Alessandro Chiarotto^{1

2}, Ulrike Kaiser^{3

4}, Ernest Choy^{3

4}, Robin Christensen^{3

4}, Philip G Conaghan^{3

4}, Mary Cowern^{3

4}, Michael Gill^{3

4}, Maarten de Wit^{3

4}, Elizabeth Gargon^{3

4}, Ben Horgan^{3

4}, Jamie J Kirkham^{3

4}, Lee S Simon^{3

4}, Jasvinder A Singh^{3

4}, Peter Tugwell^{3

4}, Dennis C Turk^{3

4}, Philip J Mease^{3

4}

Affiliations

¹ From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. a.chiarotto@vu.nl.
² A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. a.chiarotto@vu.nl.
³ From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
⁴ A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine.

PMID: 30936284
DOI: 10.3899/jrheum.181099

Abstract

Objective: Establishing a research agenda on standardizing pain measurement in clinical trials in rheumatic and musculoskeletal diseases (RMD).

Methods: Discussion during a meeting at the Outcome Measures in Rheumatology (OMERACT) 2018, prepared by a systematic review of existing core outcome sets and a patient online survey.

Results: Several key questions were debated: Is pain a symptom or a disease? Are pain core (sub)domains consistent across RMD? How to account for pain mechanistic descriptors (e.g., central sensitization) in pain measurement?

Conclusion: Characterizing and assessing the spectrum of pain experience across RMD in a standardized fashion is the objective of the OMERACT Pain Working Group.

Keywords: MEASUREMENT; MUSCULOSKELETAL HEALTH; OMERACT; PAIN; RHEUMATOLOGY.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chronic Pain / diagnosis*
Consensus
Health Surveys
Humans
Musculoskeletal Diseases / physiopathology*
Outcome Assessment, Health Care / methods*
Pain Measurement / methods*
Public Opinion
Quality of Life
Rheumatic Diseases / physiopathology*
Rheumatology / methods

Abstract

Publication types

MeSH terms

Grants and funding