Once and Only Once

Susan Gasser

doi:10.1016/j.cell.2019.03.034

Once and Only Once

Cell. 2019 Apr 18;177(3):495-498. doi: 10.1016/j.cell.2019.03.034. Epub 2019 Apr 2.

Author

Susan Gasser¹

Affiliation

¹ Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Faculty of Natural Sciences, Klingelbergstrasse 70, 4056 Basel, Switzerland. Electronic address: susan.gasser@fmi.ch.

PMID: 30952443
DOI: 10.1016/j.cell.2019.03.034

Abstract

The 2019 Gairdner Prize will be given to John F.X. Diffley and Bruce Stillman for their groundbreaking work on the mechanisms and control of the initiation of eukaryotic DNA replication. No two people have contributed more extensively, or over a longer period of time, to enlighten us on how our genomes replicate themselves once and only once per cell cycle.

Publication types

Review

MeSH terms

Cell Cycle
Cyclin-Dependent Kinases / metabolism
DNA Replication
Eukaryota / genetics*
Origin Recognition Complex / genetics
Origin Recognition Complex / metabolism
Saccharomycetales / genetics
Simian virus 40 / genetics

Substances

Origin Recognition Complex
Cyclin-Dependent Kinases