JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility

Minhui Lin; Karin Nebral; Christoph G W Gertzen; Ithamar Ganmore; Oskar A Haas; Sanil Bhatia; Ute Fischer; Michaela Kuhlen; Holger Gohlke; Shai Izraeli; Jan Trka; Jianda Hu; Arndt Borkhardt; Julia Hauer; Franziska Auer

doi:10.1038/s41375-019-0459-z

JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility

Leukemia. 2019 Sep;33(9):2331-2335. doi: 10.1038/s41375-019-0459-z. Epub 2019 Apr 9.

Authors

Minhui Lin^{1

2}, Karin Nebral³, Christoph G W Gertzen^{4

5}, Ithamar Ganmore^{6

7

8}, Oskar A Haas³, Sanil Bhatia¹, Ute Fischer¹, Michaela Kuhlen¹, Holger Gohlke^{4

5}, Shai Izraeli⁹, Jan Trka¹⁰, Jianda Hu², Arndt Borkhardt¹, Julia Hauer^{11

12

13}, Franziska Auer^{14

15

16}

Affiliations

¹ Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Düsseldorf, Medical Faculty, Düsseldorf, Germany.
² Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 350001, Fuzhou, Fujian, China.
³ Childrens Cancer Research Institute, St. Anna Childrens Hospital, Vienna, Austria.
⁴ Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany.
⁵ John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC) & Institute for Complex Systems - Structural Biochemistry (ICS 6), Forschungszentrum Jülich GmbH, 52425, Jülich, Germany.
⁶ Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.
⁷ The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.
⁸ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
⁹ Division of Pediatric Hematology and Oncology Schneider Children's Medical Center and Tel Aviv University, Tel Aviv, Israel.
¹⁰ Pediatric Hematology/Oncology, Childhood Leukemia Investigation Prague, Prague, Czech Republic.
¹¹ Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Düsseldorf, Medical Faculty, Düsseldorf, Germany. Julia.Hauer@uniklinikum-dresden.de.
¹² Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Julia.Hauer@uniklinikum-dresden.de.
¹³ National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany. Julia.Hauer@uniklinikum-dresden.de.
¹⁴ Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Düsseldorf, Medical Faculty, Düsseldorf, Germany. Franziska.Auer@uniklinikum-dresden.de.
¹⁵ National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany. Franziska.Auer@uniklinikum-dresden.de.
¹⁶ Department of Systems Biology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Pasadena, CA, USA. Franziska.Auer@uniklinikum-dresden.de.

No abstract available

Publication types

Letter

MeSH terms

B-Lymphocytes / metabolism*
Child
Female
Genetic Predisposition to Disease / genetics*
Germ Cells / metabolism*
Humans
Janus Kinase 2 / genetics*
Male
Polymorphism, Single Nucleotide / genetics
Polymorphism, Single Nucleotide / immunology*
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Signal Transduction / genetics

Substances

JAK2 protein, human
Janus Kinase 2

Publication types

MeSH terms

Substances

Grants and funding