Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand

J Hosp Infect. 2019 Oct;103(2):151-155. doi: 10.1016/j.jhin.2019.04.004. Epub 2019 Apr 14.

Abstract

Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay.

Keywords: Antimicrobial resistance; Carbapenem resistance; Colonization; Extended-spectrum beta-lactamase; Neonate.

MeSH terms

  • Carrier State / epidemiology*
  • Carrier State / microbiology
  • Drug Resistance, Bacterial*
  • Female
  • Gram-Negative Bacteria / drug effects*
  • Gram-Negative Bacteria / isolation & purification*
  • Gram-Negative Bacterial Infections / epidemiology*
  • Gram-Negative Bacterial Infections / microbiology
  • Humans
  • Infant
  • Infant, Newborn
  • Intensive Care Units, Neonatal*
  • Longitudinal Studies
  • Male
  • Thailand / epidemiology
  • beta-Lactamases / genetics

Substances

  • beta-Lactamases