Whole-Blood Testing for Diagnosis of Acute Zika Virus Infections in Routine Diagnostic Setting

Jolanda J C Voermans; Suzan D Pas; Anne van der Linden; Corine GeurtsvanKessel; Marion Koopmans; Annemiek van der Eijk; Chantal B E M Reusken

doi:10.3201/eid2507.182000

Whole-Blood Testing for Diagnosis of Acute Zika Virus Infections in Routine Diagnostic Setting

Emerg Infect Dis. 2019 Jul;25(7):1394-1396. doi: 10.3201/eid2507.182000. Epub 2019 Jul 17.

Authors

Jolanda J C Voermans, Suzan D Pas, Anne van der Linden, Corine GeurtsvanKessel, Marion Koopmans, Annemiek van der Eijk, Chantal B E M Reusken

Abstract

We evaluated the benefit of whole blood versus plasma to detect acute Zika virus infections. Comparison of Zika virus quantitative reverse transcription PCR results in single timepoint whole blood-plasma pairs from 227 patients with suspected Zika virus infection resulted in confirmation of 8 additional patients with Zika virus infection.

Keywords: RT-PCR; Zika virus; diagnosis; diagnostics; viruses; whole blood.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Diagnostic Tests, Routine* / methods
Humans
RNA, Viral / blood
RNA, Viral / genetics
Real-Time Polymerase Chain Reaction
Serologic Tests* / methods
Zika Virus Infection / diagnosis*
Zika Virus Infection / virology*
Zika Virus* / classification
Zika Virus* / genetics

Substances

RNA, Viral