CNS germinoma with extensive calcification: An unusual histologic finding

Malays J Pathol. 2019 Apr;41(1):71-73.

Abstract

Introduction: Intratumoral calcification is a feature that is more often observed in pineal parenchymal tumour than germinoma. We describe a 13-year-old male with pineal region germinoma demonstrating extensive intratumoral calcification.

Case report: He presented with worsening headache that was associated with fatigue, nausea and vomiting. Radiologic examination revealed a multilobular mass in the pineal region with internal calcifications. Biopsy showed a pure germinoma with unusually extensive calcification.

Discussion: Although a diagnosis may be suggested with a careful evaluation of imaging, there is no pathognomonic pattern. Thus, histologic verification is necessary for most pineal region masses.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Calcinosis / pathology*
  • Germinoma / pathology*
  • Humans
  • Male
  • Pinealoma / pathology*