OBJECTIVE. The purpose of this study was to systematically evaluate image quality, detectability of large-vessel occlusion or dissection, and diagnostic confidence in CT angiography (CTA) with virtually lowered tube current and iterative reconstruction in patients with suspected acute stroke. MATERIALS AND METHODS. Thirty patients (15 with large-vessel occlusion or dissection) underwent CTA of the supraaortal up to the intracranial arterial vessels. CTA scans were simulated as if they were made at 50% (D50), 25% (D25), and 10% (D10) of the original tube current. Image reconstruction was achieved with two levels of iterative reconstruction (A, similar to clinical reconstructions; B, two times stronger regularization). Two readers performed qualitative image evaluation considering overall image quality, artifacts, vessel contrast, detection of vessel abnormalities, and diagnostic confidence. RESULTS. Level B of iterative reconstruction was favorable regarding overall image quality and artifacts for D10, whereas level A was favorable for D100 and D50. CTA scans at D25 and both levels of iterative reconstruction still showed good vessel contrast, with even peripheral arterial branches of the anterior, middle, and posterior cerebral arteries being clearly detectable. Furthermore, CTA scans at D25 and level A of iterative reconstruction showed an adequate level of diagnostic confidence without any missed large-vessel occlusion or dissection according to evaluations by both readers. CONCLUSION. CTA with iterative reconstruction and tube currents decreased to 25% of that for original imaging is feasible without limitations in vessel contrast or detection of vessel abnormalities in patients with suspected acute stroke. Thus, the approach evaluated enables substantial reductions in radiation exposure for patients undergoing head and neck CTA.
Keywords: CT angiography; MDCT; ischemia; radiation exposure; stroke.