The relationship between deep medullary veins score and the severity and distribution of intracranial microbleeds

Abstract

Background: Microbleeds are frequently detected in normal elderly population, and their presence is associated with an increased risk of intracerebral hemorrhage, ischemic stroke and cognitive impairment. Previous histopathologic findings mainly focused on arteries and capillaries. Nevertheless, few studies investigated the relationship between venous disruption and microbleeds.

Objective: We aimed to evaluate the extent of venous disruption in vivo and assess the correlation between deep medullary veins (DMVs) disruption and the severity and distribution of intracranial microbleeds in patients with cerebral small vessel disease (cSVD).

Methods: We retrospectively reviewed the clinical, laboratory and imaging data of the patients admitted to our department who received brain MRI and presented with CSVD imaging markers. Susceptibility weighted imaging (SWI) phase images were used to observe characteristics of DMVs and derive a brain region-based DMVs visual score. SWI magnitude images were used to evaluate microbleeds. We recorded the number and distribution (lobar or deep or infratentorial) of microbleeds. One-way ANOVA and logistic-regression analysis were used to examine the association between the DMVs score and microbleeds.

Results: A total of 369 cSVD patients were analyzed, including 177 (48.0%) patients with microbleeds, among whom 81(45.8%) patients had 1-2 microbleeds and 96 (54.2%) patients had ≥3 microbleeds (extensive microbleeds). The patients' DMVs score ranged from 0 to18, with a median score of 8(6-12). Higher DMVs score was independently associated with extensive microbleeds (OR = 1.108, 95%Cl: 1.010-1.215, p = 0.03) after adjusting for gender, hypertension, hyperhomocysteinemia, Fazekas score and number of lacunas. According to the distribution, 38 (21.5%) patients were found with strict lobar microbleeds, while 139 (78.5%) patients had non-strict lobar microbleeds. Higher DMVs score was also independently associated with non-strict lobar microbleeds (OR = 1.106, 95% Cl: 1.019-1.200, p = 0.016) after adjusting for gender, hypertension, hyperhomocysteinemia, Fazekas score and number of lacunas. DMVs score was not associated with strict lobar microbleeds (p = 0.307).

Conclusion: DMVs disruption might be involved in the development of extensive microbleeds, especially non-strict lobar cerebral microbleeds.

Keywords: Cerebral microbleeds; Cerebral small vessel disease; Deep medullary veins; Susceptibility-weighted images.