Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

Sabelle Jallow; Jo M Wilmshurst; Wayne Howard; Julie Copelyn; Lerato Seakamela; Koon-Wing Chan; Robert Sebunya; Rosinah Sibiya; Heleen Du Plessis; Charlene Jacobs; Natacha Berkowitz; Lucille Blumberg; Kerrigan McCarthy; Elizabeth Maseti; Mercy Kamupira; Nonhlanhla Dlamini; Nicksy Gumede; Ousmane M Diop; Yu Lung Lau; Shelina Moonsamy; Brian Eley; Melinda Suchard

doi:10.1093/cid/ciz361

Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

Clin Infect Dis. 2020 Jan 1;70(1):132-135. doi: 10.1093/cid/ciz361.

Authors

Sabelle Jallow¹, Jo M Wilmshurst², Wayne Howard¹, Julie Copelyn^{3

4}, Lerato Seakamela¹, Koon-Wing Chan⁵, Robert Sebunya², Rosinah Sibiya¹, Heleen Du Plessis¹, Charlene Jacobs⁶, Natacha Berkowitz⁷, Lucille Blumberg⁸, Kerrigan McCarthy⁹, Elizabeth Maseti¹⁰, Mercy Kamupira¹¹, Nonhlanhla Dlamini¹⁰, Nicksy Gumede¹², Ousmane M Diop¹³, Yu Lung Lau⁵, Shelina Moonsamy¹, Brian Eley^{3

4}, Melinda Suchard^{1

14}

Affiliations

¹ Centre for Vaccines and Immunology, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg.
² Department of Paediatric Neurology, Neuroscience Institute, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa.
³ Paediatric Infectious Diseases Unit, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa.
⁴ Department of Paediatrics and Child Health, University of Cape Town, South Africa.
⁵ Department of Paediatrics and Adolescent Medicine, University of Hong Kong, China.
⁶ Division of Public Health, Surveillance and Response, Department of Health, Provincial Government of the Western Cape, Cape Town.
⁷ Department of City Health, Social Services Directorate, Cape Town.
⁸ Public Health Surveillance and Response Division, Johannesburg.
⁹ Outbreak Response Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg.
¹⁰ Child, Youth and School Health, National Department of Health, Pretoria, South Africa.
¹¹ World Health Organization (WHO) Country Office, Pretoria, South Africa.
¹² WHO Regional Office for Africa, Brazzaville, Republic of Congo.
¹³ Polio Department, WHO Strategic Initiatives Cluster, Geneva, Switzerland.
¹⁴ Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Abstract

Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.

Keywords: Bruton tyrosine kinase; HIV-exposed but uninfected; X-linked agammaglobulinemia; acute flaccid paralysis; oral poliovirus vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Agammaglobulinemia*
Child
Genetic Diseases, X-Linked
HIV / genetics
Humans
Male
Poliomyelitis*
Poliovirus Vaccine, Oral / adverse effects
Poliovirus* / genetics
Serogroup

Substances

Poliovirus Vaccine, Oral

Supplementary concepts

Bruton type agammaglobulinemia

Grants and funding

001/WHO_/World Health Organization/International