Molecular Typing of Multiple Isolates Is Essential to Diagnose Cutibacterium acnes Orthopedic Device-related Infection

Faten El Sayed; Anne-Laure Roux; Guillaume Sapriel; Elsa Salomon; Thomas Bauer; Jean-Louis Gaillard; Martin Rottman

doi:10.1093/cid/ciy952

Molecular Typing of Multiple Isolates Is Essential to Diagnose Cutibacterium acnes Orthopedic Device-related Infection

Clin Infect Dis. 2019 May 17;68(11):1942-1945. doi: 10.1093/cid/ciy952.

Authors

Faten El Sayed^{1

2}, Anne-Laure Roux^{1

2}, Guillaume Sapriel^{3

4}, Elsa Salomon^{1

2}, Thomas Bauer^{3

5}, Jean-Louis Gaillard^{1

2}, Martin Rottman^{2

6}

Affiliations

¹ Department of Microbiology, Hôpital Ambroise Paré, Boulogne-Billancourt.
² Unité mixte de recherche, Inserm.
³ Faculté Des Sciences de la Santé Simone Veil, University of Versailles Saint-Quentin, Montigny-le-Bretonneux.
⁴ Atelier de Bioinformatique, Paris.
⁵ Orthopedic Surgery Department, Hôpital Ambroise Paré, Boulogne-Billancourt.
⁶ Microbiology Department, Hôpital Raymond Poincaré, Garches, France.

PMID: 31098616
DOI: 10.1093/cid/ciy952

Abstract

Cutibacterium acnes orthopedic device-related infections (ODRIs) range from obvious infections to solely culture-based diagnoses. Multilocus sequence typing of multiple isolates from the same procedure revealed that most cases with normal C-reactive protein levels that were classified as C. acnes ODRI would be considered contaminations when accounting for genotypic data.

Keywords: Cutibacterium acnes; bone and joint infection; heterotypic; multilocus sequence typing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Bacterial Typing Techniques
Equipment Contamination*
Female
Genotype
Gram-Positive Bacterial Infections / diagnosis*
Gram-Positive Bacterial Infections / microbiology*
Humans
Male
Middle Aged
Multilocus Sequence Typing*
Propionibacterium acnes / classification*
Propionibacterium acnes / isolation & purification