In utero embolization for placental chorioangioma and neonatal multifocal hemangiomatosis

J Gynecol Obstet Hum Reprod. 2019 Oct;48(8):689-694. doi: 10.1016/j.jogoh.2019.05.011. Epub 2019 May 18.

Abstract

Placental chorioangioma is a limited non trophoblastic vascular tumour that may causes fetal complications as well as post-natal ones. We reported in here the first case of an in utero embolization of chorioangioma diagnosed at 22 W G with a post-natal diagnosis of neonatal multifocal hemangioma with a good outcome. The chorioangioma was embolized using GLUBRAN 2 ® (cyanolacrylate) a biologic surgical glue at 26 W G. Premature rupture of membrane occurred at 28 W G. A cesarean section at 32 W G was performed for retro placental hematoma. The neonate was 1400 g healthy girl with an anemia (hemoglobin 9.7 g/dl). After one month of life, the child met a neonatal multifocal hemangioma (skin and liver were involved) with superficial erosion of skin hemangiomas that required post-natal transfusions. We propose a literature review related to the various technics of in utero treatment of placental chorioangioma and the links with neonatal multifocal hemangiomatosis as well. The girl is now 7 year old and has a normal neurodevelopmental outcome.

Keywords: Embolization; Infantile hemangioma; Neonatal multifical hemangiomatosis; Placental chorioangioma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Embolization, Therapeutic* / methods
  • Female
  • Fetoscopy / methods*
  • Hemangioma / pathology
  • Hemangioma / therapy*
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / etiology
  • Infant, Newborn, Diseases / therapy*
  • Neoplasms, Multiple Primary / pathology
  • Neoplasms, Multiple Primary / therapy
  • Placenta Diseases / pathology
  • Placenta Diseases / therapy*
  • Pregnancy
  • Pregnancy Complications, Neoplastic / pathology
  • Pregnancy Complications, Neoplastic / therapy*
  • Skin Neoplasms / etiology
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*