[Characteristics of the inhibition of thymus endocrine function and synthesis of substances with thymosin-like activity caused by thymostimulin and splenin during DMBA-induced mammary gland carcinogenesis in rats]

Abstract

The contents of thymic hormones and endogenous substances with thymosin-like activity (TLA) was studied under conditions of administering thymostimulin and splenin during DMBA-induced carcinogenesis in rat mammary glands. It has been established that during latent carcinogenesis there is an inhibition of thymic endocrine function which persists in tumour-bearing animals. Injections of thymostimulin and splenin induce synthesis of substances with TLA, accompanied by an inhibition of blastoma development.