Snatch-and-Grab Inhibitors to Fight the Flu

Cell. 2019 May 30;177(6):1367. doi: 10.1016/j.cell.2019.05.033.

Abstract

Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10-20 nucleotides of 5' capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.

MeSH terms

  • Dibenzothiepins
  • Endonucleases / genetics
  • Humans
  • Influenza, Human / drug therapy*
  • Morpholines
  • Orthomyxoviridae / drug effects
  • Orthomyxoviridae / pathogenicity
  • Oxazines / pharmacology*
  • Oxazines / therapeutic use*
  • Pyridines / pharmacology*
  • Pyridines / therapeutic use*
  • Pyridones
  • RNA Caps / genetics
  • RNA, Messenger / genetics
  • RNA, Viral / genetics
  • Thiepins / pharmacology*
  • Thiepins / therapeutic use*
  • Triazines / pharmacology*
  • Triazines / therapeutic use*
  • Viral Proteins / genetics

Substances

  • Dibenzothiepins
  • Morpholines
  • Oxazines
  • Pyridines
  • Pyridones
  • RNA Caps
  • RNA, Messenger
  • RNA, Viral
  • Thiepins
  • Triazines
  • Viral Proteins
  • baloxavir
  • Endonucleases