Abstract
Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10-20 nucleotides of 5' capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.
Copyright © 2019 Elsevier Inc. All rights reserved.
MeSH terms
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Dibenzothiepins
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Endonucleases / genetics
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Humans
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Influenza, Human / drug therapy*
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Morpholines
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Orthomyxoviridae / drug effects
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Orthomyxoviridae / pathogenicity
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Oxazines / pharmacology*
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Oxazines / therapeutic use*
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Pyridines / pharmacology*
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Pyridines / therapeutic use*
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Pyridones
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RNA Caps / genetics
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RNA, Messenger / genetics
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RNA, Viral / genetics
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Thiepins / pharmacology*
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Thiepins / therapeutic use*
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Triazines / pharmacology*
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Triazines / therapeutic use*
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Viral Proteins / genetics
Substances
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Dibenzothiepins
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Morpholines
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Oxazines
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Pyridines
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Pyridones
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RNA Caps
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RNA, Messenger
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RNA, Viral
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Thiepins
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Triazines
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Viral Proteins
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baloxavir
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Endonucleases