Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India

Microb Drug Resist. 2019 Jun;25(5):677-680. doi: 10.1089/mdr.2018.0408.

Abstract

Candida auris is an emerging multidrug-resistant yeast with high mortality. We report the sentinel C. auris case on the United States West Coast in a patient who relocated from India. We identified close phylogenetic relatedness to the South Asia clade and ERG11 Y132F and FKS1 S639Y mutations potentially explaining antifungal resistance.

Keywords: antimicrobial resistance; echinocandin resistance; emerging infection; metagenomic.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents / pharmacology*
  • California
  • Candida / classification
  • Candida / genetics*
  • Candida / isolation & purification
  • Candida / pathogenicity
  • Candidiasis / complications
  • Candidiasis / drug therapy
  • Candidiasis / microbiology*
  • Candidiasis / pathology
  • Drug Resistance, Multiple, Fungal / genetics*
  • Echinocandins / pharmacology
  • Fatal Outcome
  • Fluconazole / pharmacology
  • Humans
  • India
  • Male
  • Microbial Sensitivity Tests
  • Phylogeny
  • Rectal Neoplasms / complications
  • Rectal Neoplasms / drug therapy
  • Rectal Neoplasms / microbiology*
  • Rectal Neoplasms / pathology
  • Sentinel Surveillance
  • Travel

Substances

  • Antifungal Agents
  • Echinocandins
  • Fluconazole