Presence of antibodies against low-density lipoprotein receptor-related protein 4 and impairment of neuromuscular junction in a Chinese cohort of amyotrophic lateral sclerosis

Chin Med J (Engl). 2019 Jun 20;132(12):1487-1489. doi: 10.1097/CM9.0000000000000284.

Authors

Affiliations

¹ Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
² Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
³ Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Key Laboratory of Neurodegeneration, Ministry of Education, Beijing 100053, China.

Abstract

Supplemental Digital Content is available in the text

MeSH terms

Amyotrophic Lateral Sclerosis / immunology*
Amyotrophic Lateral Sclerosis / metabolism*
Antibodies / immunology
Antibodies / metabolism*
HEK293 Cells
Humans
LDL-Receptor Related Proteins / antagonists & inhibitors*
LDL-Receptor Related Proteins / immunology
Neuromuscular Junction / immunology*
Neuromuscular Junction / metabolism*

Substances

Antibodies
LDL-Receptor Related Proteins
LRP4 protein, human