A 65-year-old man with gastric cancer showing multiple liver metastases was treated with recombinant interferon-gamma (KW-2202) and 5-fluorouracil (5-FU). Three months after this combination therapy, the metastatic liver masses showed remarkable reduction in both number and size. Also, the primary gastric tumor showed a definite size reduction. Judging from these findings, subtotal gastrectomy and resection of the metastatic liver mass were performed. This case of gastric cancer with multiple liver metastases was thus shown to well to combination therapy with KW-2202 and 5-FU.