Circadian rhythm of exhaled biomarkers in health and asthma

Maxim Wilkinson; Robert Maidstone; Andrew Loudon; John Blaikley; Iain R White; Dave Singh; David W Ray; Royston Goodacre; Stephen J Fowler; Hannah J Durrington

doi:10.1183/13993003.01068-2019

Circadian rhythm of exhaled biomarkers in health and asthma

Eur Respir J. 2019 Oct 17;54(4):1901068. doi: 10.1183/13993003.01068-2019. Print 2019 Oct.

Authors

Maxim Wilkinson¹, Robert Maidstone^{2

3

4}, Andrew Loudon⁵, John Blaikley^{1

6}, Iain R White^{1

7}, Dave Singh^{1

8}, David W Ray^{2

3}, Royston Goodacre^{9

10}, Stephen J Fowler^{1

6}, Hannah J Durrington¹¹

Affiliations

¹ Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
² NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.
³ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
⁴ Division of Informatics, Imaging and Data Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
⁵ Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
⁶ Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
⁷ Laboratory for Environmental and Life Sciences, University of Nova Gorica, Nova Gorica, Slovenia.
⁸ Medicines Evaluation Unit (MEU), Langley Building, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
⁹ School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
¹⁰ Dept of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
¹¹ Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK hannah.durrington@manchester.ac.uk.

Abstract

Exhaled volatile chemicals and fractional exhaled nitric oxide oscillate over 24 h, highlighting the importance of time of day in diagnostic sampling and suggesting potential applications for chronotyping. http://bit.ly/2YZGXbH

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Asthma / metabolism*
Asthma / physiopathology
Biomarkers / metabolism*
Breath Tests
Case-Control Studies
Circadian Rhythm*
Forced Expiratory Volume
Gas Chromatography-Mass Spectrometry
Humans
Nitric Oxide / metabolism*
Volatile Organic Compounds / metabolism*

Substances

Biomarkers
Volatile Organic Compounds
Nitric Oxide

Abstract

Publication types

MeSH terms

Substances

Grants and funding