Biological activity of aqueous extracts of Southern Brazilian mushrooms

Int J Environ Health Res. 2021 Mar;31(2):148-159. doi: 10.1080/09603123.2019.1634798. Epub 2019 Jul 1.

Abstract

This study aims to perform a bioactive analysis of five mushrooms collected in south of Brazil. The total phenol content of the extracts was equivalent to the antioxidant activity by ACAP assay. All extracts were able to inhibit the growth of Acinetobacter baumanni, and Auricularia auricula and Lactarius deliciosus extract showed the best antibacterial activity. In addition, no extract showed cytotoxic activity against VERO cells at the highest concentration evaluated (2500 µg/mL). Our results showed better antioxidant activity through the inhibition of the oxidation via peroxyl radical. It can be observed that all extracts were active against A. baumanni, and even moderately, all extracts could be inhibited of at least one of the bacteria used in the study. Added for these, the aqueous extracts showed no toxicity in VERO cells, highlighting the importance of research about the active compounds of mushrooms of the region.

Keywords: Antioxidant potential; antibacterial activity; basydiomicetes; biome pampa.

MeSH terms

  • Acinetobacter baumannii / drug effects
  • Agaricales / chemistry*
  • Agaricales / growth & development
  • Agaricales / metabolism
  • Animals
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / toxicity
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Antioxidants / toxicity
  • Brazil
  • Cell Survival / drug effects
  • Chlorocebus aethiops
  • Escherichia coli / drug effects
  • Klebsiella pneumoniae / drug effects
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects
  • Streptococcus pneumoniae / drug effects
  • Vero Cells

Substances

  • Anti-Bacterial Agents
  • Antioxidants