Potential inhibitors of platelet aggregation from plant sources, III

H S Yun-Choi; J H Kim; J R Lee

doi:10.1021/np50054a008

Potential inhibitors of platelet aggregation from plant sources, III

J Nat Prod. 1987 Nov-Dec;50(6):1059-64. doi: 10.1021/np50054a008.

Authors

H S Yun-Choi¹, J H Kim, J R Lee

Affiliation

¹ Natural Products Research Institute, Seoul National University, Korea.

PMID: 3127544
DOI: 10.1021/np50054a008

Abstract

3,4-Dihydroxybenzoic acid (DBA) was isolated from Acanthopanax senticosus as an antiplatelet aggregatory substance. This paper also reports the results of the investigations on the structural activity relationships among the various dihydroxybenzoic acid derivatives against rat platelet aggregations induced by ADP (adenosine 5'-diphosphate), AA (arachidonic acid), or collagen.

MeSH terms

Adenosine Diphosphate / pharmacology
Animals
Arachidonic Acid
Arachidonic Acids / pharmacology
Chemical Phenomena
Chemistry
Collagen / pharmacology
In Vitro Techniques
Magnetic Resonance Spectroscopy
Plants, Medicinal / analysis*
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / isolation & purification
Platelet Aggregation Inhibitors / pharmacology*
Rats

Substances

Arachidonic Acids
Platelet Aggregation Inhibitors
Arachidonic Acid
Adenosine Diphosphate
Collagen