Association Mapping and Disease: Evolutionary Perspectives

Methods Mol Biol. 2019:1910:533-553. doi: 10.1007/978-1-4939-9074-0_17.

Abstract

In this chapter, we give a short introduction to the genetics of complex diseases emphasizing evolutionary models for disease genes and the effect of different models on the genetic architecture, and we give a survey of the state-of-the-art of genome-wide association studies (GWASs).

Keywords: Association mapping; Common disease/common variant; Complex diseases; Genome-wide association studies.

Publication types

  • Review

MeSH terms

  • Alleles
  • Chromosome Mapping*
  • Computational Biology / methods
  • Confounding Factors, Epidemiologic
  • Evolution, Molecular
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genetic Variation*
  • Genome-Wide Association Study*
  • Humans
  • Models, Genetic
  • Models, Statistical