Catalyst- and Additive-Free Cascade Reaction of Isoquinoline N-Oxides with Alkynones: An Approach to Benzoazepino[2,1- a]isoquinoline Derivatives

Xuetong Li; Guanghua Zhou; Xinru Du; Tao Wang; Zunting Zhang

doi:10.1021/acs.orglett.9b01966

Catalyst- and Additive-Free Cascade Reaction of Isoquinoline N-Oxides with Alkynones: An Approach to Benzoazepino[2,1- a]isoquinoline Derivatives

Org Lett. 2019 Jul 19;21(14):5630-5633. doi: 10.1021/acs.orglett.9b01966. Epub 2019 Jul 9.

Authors

Xuetong Li¹, Guanghua Zhou², Xinru Du¹, Tao Wang¹, Zunting Zhang¹

Affiliations

¹ Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering , Shaanxi Normal University , No. 620 West Chang'an Avenue , Xi'an 710119 , China.
² Department of Chemistry , Nanchang Normal University , No. 889 Ruixiang Road , Nanchang 330032 , China.

PMID: 31287323
DOI: 10.1021/acs.orglett.9b01966

Abstract

A cascade reaction of isoquinoline N-oxides with alkynones was developed, delivering a fluorescent benzoazepino[2,1-a]isoquinoline derivative. The reaction worked smoothly without requirement of any catalyst or additive, making this method economical and easy to handle.